Beneficial effects of chaulmoogra in leprous neuritis

1- Attention should be given to the neural disturbances of leprosy, and they should be treated early because the grave sequelae in advanced cases cannot respond to any antileprosy medication we have at present. 2- The lesion s of moderate neuritis in lepromatous cases generally respond very poorly to sulfone medication, according to the experience of many leprologists, including myself. 3- This type of neuritis, according to my experience, can be arrested and made to regress in a high percentage of cases, even those which have not responded to prolonged sulfone medication, when given chaulmoogra in sufficient dosage (20-30 cc. weekly). 4- The symptoms which are most benefited are, among the subjective ones: numbness, cramps, pains, pruritus, hot sensation, and diminution of strength of the limbs, and among the objective ones: bullae, trophic ulcers, and in some cases mild and recent muscular atrophy. 5- It is suggested that, in similar moderate cases which do not respond to modern leprosy medication, a trial of the old chaulmoogra treatment be made, employing sufficient dosage.

Semillas y aceites antileprosos

En los generos que pertencen a la familia de las flacourciáceas existen numerosas especies cuyas semillas poseen una elevada proproción de sustancias grasas que presentam un interés extraordinario desde el punto de vista terapeutico. El examen de la bibliografia que a esta materia se refiere descubre la dificultad que entraña el conseguir una sistematización de los datos hasta ahora aportados por los investigadores. Con la excepción de escasas especies de estas plantas, que han sido bien estudiadas desde el punto de vista botánico y quimico, el resto aparece difuso y complejo

Hunting the chaulmoogra tree

"CHAUOLMOOGRA" is no longer a strange-sounding name, for of late it has appeared frequently in newspaper dispatches as a possible cure for leprosy, and in fact two constituents of Chaulmoogra oil, chaulmoogric and hydnocarpic acids, but especially their ethyl esters, have proved efficacious in the treatment of that dreadful disease. These acids were first isolated and described and their esters prepared nearly twenty years ago by Dr. Frederick B. power and his assistants

A summary of recent developments in the chemistry of leprosy therapy

In reviewing recent progress in the chemistry of leprosy treatment one is not impressed so much by any really new discovery as by the fact that so little was definitely known or generally accepted five years ago. It is not difficult to pick out important facts now widely accepeted and made use of in the treatment of leprosy, and to note that someone knew (or at least believed) this, that, and the other, ten, one hundred, or one thousand years ago. It is important, however, to recall that such quasi knowledge was so confounded with erroneous beliefs as to have very little effective value

Sodium hydnocarpate in leprosy, suggested improvements in administration

1) While the intravenous injection of sodium hydnocarpate may be admitted as the most effective means of administering hydnocarpus preparations, the blocking of veins has hitherto interfered with prolonged administration in this way.2) The sodium salts derived from a special fraction of H. wightiana and also the sodium salts of H. anthelmintica and alpina block the veins less than the salts from the whole H. wightiana oil.3) A new method of mixing the salts prepared from the whole oil of H. wightiana with blood before injection has received vein-blocking to a much more marked extent.4) Alternation of intravenous sodium hydnocarpate with subcutaneous infiltration of hydnocarpus oil with creosote is advised chiefly because of the haemolytic effect of the former preparations.

Note preliminaire sur le traitement de la lèpre par les ethers ethyliques de l´huile de Chaulmoogra

Malgré le bruit fait autour de récentes tentatives thérapeutiques, le traite par l'huile de Chaulmoogra semble bien demeurer la base de la médication anti-hansénienne. C'est à coup sûr ce produit qui donne la plus forte proportion de résultats encourageants dans une aussi désespérante entreprise. Tous les léprologues paraissent d'accord sur ce point si tous n'osent prononcer le mot de spécificité affirmée par quelquesuns

A cura da lepra

O chamado Mal de HAnsen, a lepra, é curável. Não é só curável, mas pode, como a varíola e outros flagelos, admitir um tratamento preventivo. De qualquer modo, pelo menos, sua propagação não se dará mais com a intensidade antiga. Um nome - Fernando Terra - inscrever-se-á, desde agora, a título de benemerência, entre os dos brasileiros ilustres que bem serviram a seu país. Há no combate a lepra, de fato, a marca indiscutível do patriotismo. Os leprosos, cuja situação estatística é mais alarmante no interior do Pará, de Minas Gerais, de São Paulo e do Paraná, existem um pouco em toda parte pelo Barsil. existem e multiplicam-se